Joint Genomic Prediction of Canine Hip Dysplasia in UK and US Labrador Retrievers
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چکیده
منابع مشابه
Joint Genomic Prediction of Canine Hip Dysplasia in UK and US Labrador Retrievers
Canine hip dysplasia, a debilitating orthopedic disorder that leads to osteoarthritis and cartilage degeneration, is common in several large-sized dog breeds and shows moderate heritability suggesting that selection can reduce prevalence. Estimating genomic breeding values require large reference populations, which are expensive to genotype for development of genomic prediction tools. Combining...
متن کاملGenetic Evaluation of Hip Score in UK Labrador Retrievers
Hip dysplasia is an important and complex genetic disease in dogs with both genetic and environmental influences. Since the osteoarthritis that develops is irreversible the only way to improve welfare, through reducing the prevalence, is through genetic selection. This study aimed to evaluate the progress of selection against hip dysplasia, to quantify potential improvements in the response to ...
متن کاملGenomic prediction of traits related to canine hip dysplasia
Increased concern for the welfare of pedigree dogs has led to development of selection programs against inherited diseases. An example is canine hip dysplasia (CHD), which has a moderate heritability and a high prevalence in some large-sized breeds. To date, selection using phenotypes has led to only modest improvement, and alternative strategies such as genomic selection (GS) may prove more ef...
متن کاملChronology of hip dysplasia development in a cohort of 48 Labrador retrievers followed for life.
OBJECTIVE To determine the chronology of radiographic signs of canine hip dysplasia (CHD), specifically joint laxity and secondary osteoarthritis (OA). STUDY DESIGN Longitudinal cohort study. ANIMALS Paired littermates, 48 Labrador retrievers. METHODS Conventional, ventrodorsal, hip-extended (HE) radiographs were evaluated yearly for CHD according to the subjective criteria of the Orthope...
متن کاملGenetic Evaluation of the Nine Component Features of Hip Score in UK Labrador Retrievers
The aim of this study was to explore the genetic relationship between the nine component traits comprising the British Veterinary Association (BVA) total hip score in UK registered Labrador Retrievers. Data consisted of 11,928 single records of trait scores of dogs aged between one and four years (365-1459 days) old, from radiographs evaluated between 2000 and 2007. Pedigree information was pro...
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ژورنال
عنوان ژورنال: Frontiers in Genetics
سال: 2018
ISSN: 1664-8021
DOI: 10.3389/fgene.2018.00101